Looking back on it now, Prison Break ended up being pretty crappy over its total life.
They should have either just kept it a one season show or maybe done it in a serial style show. Give a new setting & circumstances of a breakout, some seasons they make it, others they don't... it could work.
What they did with the actual show was just a recipe for disaster. The show held up well through S1. S2, they tried to stay so action focused that they burned (killed) off too many characters too fast that they lost all of their creative basis. By S3-S4, it was just a downward spiral of growing conspiracy and constant turning on each other. It was just a soap opera on crank at the end there, every 15 minutes, someone turned on someone and had new partners.