There is only one undefeated school left, so the Big 10, ACC, and PAC12 Champ is going to have at least one loss, maybe more than one loss before everything is all done. Its a reach, but if Oklahoma, with losses to Ohio State and Clemson (was it Clemson?) wins the Big12 without a conference loss, I could see the argument for it. It could only be Oklahoma though, and even then, it would be tough.
What I took away from this weekend is that this year, there is BAMA, and then there is everyone else, pretty far behind.
EDIT: Actually if WV wins their remaining games they would be Big12 Champions with only one loss. Still, considering how fucked up the conference is, the most realistic chance a Big 12 school has to make the playoff is to go undefeated in the regular season.