In Cyber-Lip players control Rick (P1) and Brook (P2) and must battle through large numbers of enemies. In addition to the normal gun, the player can gain and use other weapons such as flamethrowers and rocket launchers, however ammunition is limited and players can switch weapons to conserve ammo. In between stages the player has to choose whether to ascend or descend in an elevator which will randomly determine if the player will proceed to the next stage. If the player picks the wrong elevator button, the player will have to traverse through a dangerous sub-level before proceeding to the next stage.
In the year 2016 the federal government approved a space colony project in response to global overpopulation. By 2019, the Colony CO5 was turned into a stronghold for androids. However, many androids were found to be defective. The next year, the government had a supercomputer called Cyber-Lip built to control the androids, which were then trained to combat an incoming alien invasion. Now the year is 2030 and humankind is in jeopardy from the alien and maverick android forces combined. Two of the military's best veteran androids, Rick and Brook, have been sent as a last-ditch effort to repel the invaders and destroy the rogue Cyber-Lip.