The issue with the 120 in 1 is its missing tonnes of 100nF bypass caps, needs 2 x 47pF caps to fix sound glitches and ideally you should swap out the diodes for a voltage regulator. I've done videos on this recently. The lack of those caps, coupled with a poor PSU or bad caps on your MVS will result in random crashes, sound glitches etc.
As SmokeMonsters says - the 161 in 1 tends to be better, but even that can suffer sound glitches, albeit a lot less than any of the other multicarts, but you can also improve that by adding 2 x 47pF caps, and you can (and probably should if you want it to last, swap out the 2 diodes on the prog board with a 3.3v regulator.