Clean the cart slot, give it a really good clean, and check the pins if they are all Ok ( aligned and check if you have any pin down or broken,etc)
Get an old visa card, with an old T-shirt around it...use a good PCB cleaner and clean those pins very gentle
( There's some YouTube videos on this )
Also you may need to adjust the cart on that slot ( bit up, or down, ) my 4slot is very temperamental on this
... If I push the game all the way down, on slots 2, and 3, I get gfx corrupted graphics and/or no sound , etc...
Cheers