As others have mentioned, yes, the DC could easily handle MS3. It's just a matter of effective programming.
The OG Xbox port of MS3 was flawless. One of the best Neo ports I ever played.
Hit the breaks for a second there...great port? It's a good port, flawless? Hell no but to the untrained eye that focuses on smelling carts...then yeah it's pretty damn good.
The problem with that port is the pixel scrolling which performs well on a CRT 'cause it can't be noticed, now keep in mind this game runs in 480i only, again 480i only...that alone is a bummer...timing is good though and I like the fact that you have to re-start the stage from the beginning if you're gonna credit feed, makes it more compelling for them credit feeders.
The XBL was filtered but it's pretty much up on the same bar with the XBOX port. The PS2 port (not anthology) is really decent, right up there with the XBOX port, same problems.
Emulation still beats all the ports.