The Spawn is calling me as well...
Not sure about that new game, but well, let's see how it turns out. Most developers, directors and artists seem to have troubles bringing Yog Sothoth mythos plots and deities to life (just look at all those abysmal movie productions), and it's my inspired guess that this will be the case here as well.
About the CoC pen-and-paper RPG, I've DM'd that a lot during the past few years but since my usual RPG players are focussed on high-fantasy RPGs such as Rolemaster, we never got into it that deeply, and if we did, it wasn't really all that because we all know Lovecraft's and other mythos authors' novels inside out which makes it difficult to set up proper standard encounters based on the usual parameters such as smell, certain remote noises, etc. Usual conversation: "After opening the door you see dark, vibrant smoke that emerges from one of the corners of the room, and"... Player: "Ah, a Hound of Tindalos, I'll summon a Nightghaunt to get rid of him!".... you know the score... that's why my campaigns tend to be completely on the mystic side, with challenges for the players' brains, not so much their characters' weapons, magical scrolls, resistance potions, artefacts, connections to mythos minions, etc.
This goes on up to a point where only the basic rules of the whole standard and companion rulesets apply and the DM gets full control over the party again. IMO, this is tricky to achieve without letting the players feel that despite their mental and physical powers, they just meet even bigger opponents that render their newly-aquired magic, artefact, etc. useless, which often leads to lame discussions...
A lot of my adventures during complete sets of campaigns deal with the base for most mythos lore, the books, the black tomes of the Yog Sothoth legend. It's very interesting to build a plot on that specially if your players are very HPL-savvy and have read the occasional book on occult topics.
I just love the Chaosium CoC rule- and sourcebooks, very good material. One of my fave is Arkham Unveiled (Chaosium #2325) which fueled dozens of our smaller Arkham/Miscatonic area/Dunwich/Innsmouth adventures and campaigns with nice plots and stories.