Nope, it won't "take off," but as long as it continues to receive at least a decent amount of support from SNK and Sammy, it will be well worth owning. Owning one is an easy choice if you love 2-D or SNK (likely both if one). I know it's going to be 4 figures when it launches, but to be able to play NBC on the original hardware will be great, even though my wallet will hate me for it. Same with Metal Slug 6, and with Sam Spirits 6, etc...
I actually consider that part of the charm, that it won't "take off." While most of the mainstream gaming world asks "what the hell is that?" (Actually the response I got at my local Gamestop when a friend of mine who works there asked what I was playing lately), I'm at home enjoying the hell out of Guilty Gear Isuka on the intended platform.